DNA Damage and Aging of the Corneal Endothelium

Research Description

  • Corneal endothelium (CE) is the posterior tissue layer of the cornea and is critical for maintenance of corneal hydration and transparency.
  • Aging, UV light from sun exposure, or some drugs used in refractive surgery contribute to DNA damage in the CE.
  • This project examines the roles of cell-cell communications in the CE response to DNA damage with the goals of preserving CE function in corneas compromised by natural aging or other cellular stressors.