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DNA Damage and Aging of the Corneal Endothelium
- Corneal endothelium (CE) is the posterior tissue layer of the cornea and is critical for maintenance of corneal hydration and transparency.
- Aging, UV light from sun exposure, or some drugs used in refractive surgery contribute to DNA damage in the CE.
- This project examines the roles of cell-cell communications in the CE response to DNA damage with the goals of preserving CE function in corneas compromised by natural aging or other cellular stressors.