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Cell-Cell Interactions in Corneal homeostasis
- The cornea consists of specialized tough transparent connective tissue sparsely populated by cells, the keratocytes. Keratocytes maintain corneal transparency but after wounding these cells produce permanent opaque scar tissue.
- This project examines the role of cell-cell communications in maintenance of corneal transparency by keratocytes.
- The goal of the project is to determine the molecular signals that control production of transparent and opaque tissue by the keratocytes in order to develop therapeutic approaches to reversal of corneal scarring.